An antioxidant boehmite amino-nanozyme able to disaggregate Huntington's inclusion bodies

A novel amino-nanozyme, based on boehmite nanoparticles (BNPs) functionalised with a tetra-azapyridinophane ( L1 ), has been designed to undermine some of the key issues underlying Huntington disease. L1 forms Cu 2+ complexes with a striking SOD activity, while when grafted to the BNPs displays mitoROS scavenging properties and ability to disaggregate mutant huntingtin deposits in cells. Antioxidant amino-nanozymes shown both a prominent antioxidant activity and a striking capacity to remove mutant huntingtin aggregates.