Visible-Light Enabled C(sp 3)–C(sp 2) Cross-Electrophile Coupling via Synergistic Halogen-Atom Transfer (XAT) and Nickel Catalysis

Visible-Light Enabled C(sp 3)–C(sp 2) Cross-Electrophile Coupling via Synergistic Halogen-Atom Transfer (XAT) and Nickel Catalysis

We herein report the first visible-light-mediated cross-coupling of unactivated alkyl iodides with aryl bromides through synergistic halogen atom transfer (XAT) and nickel catalysis. This simple protocol operates under mild reaction conditions and tolerates a variety of functional groups affording C...

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Veröffentlicht in:Journal of organic chemistry 2022-04, Vol.87 (8), p.5442-5450
Hauptverfasser: Yedase, Girish Suresh, Jha, Avishek Kumar, Yatham, Veera Reddy
Format: Artikel
Sprache:eng
Schlagworte:
Bromides
Catalysis
Halogens
Nickel
Oxidation-Reduction
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Zusammenfassung:We herein report the first visible-light-mediated cross-coupling of unactivated alkyl iodides with aryl bromides through synergistic halogen atom transfer (XAT) and nickel catalysis. This simple protocol operates under mild reaction conditions and tolerates a variety of functional groups affording C­(sp 3)–C­(sp 2) cross-coupling products in good to moderate yields.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.2c00251