Stereoselective Construction of Orthogonally Protected, N–O Interlinked Disaccharide Mimetics Using N‑Substituted β‑Aminooxy Donors

Orthogonally protected N-substituted β-aminooxy sugars can be stereoselectively synthesized from sugar epoxides and nitrones derived from aromatic aldehydes. Both the ether- and ester-protected sugar epoxides can be employed. The synthesized aminooxy sugars could be reacted with aldehyde bearing/free reducing sugars under the heating condition to afford N–O-linked 1,1-/1,5/1,6-disaccharide mimetics in a good yield.