Metabolism of a New Dipeptide Neuroprotector in Rats

Metabolism of a New Dipeptide Neuroprotector in Rats

Metabolism of a new neuroprotector GZK-111 ( N -phenylacetylglycyl- L -proline ethyl ester) in rat blood plasma was studied by HPLC-mass spectrometry. Four biotransformation products were identified. It is concluded that the main ways of GZK-111 biotransformation are hydrolysis of the ester bond by...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2022-03, Vol.172 (5), p.579-582
Hauptverfasser: Kolyvanov, G. B., Bochkov, P. O., Litvin, A. A., Shevchenko, R. V., Podol’ko, A. L., Kravtsova, O. Yu, Kolyasnikova, K. N., Zherdev, V. P.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biomedical and Life Sciences
Biomedicine
Biotransformation
Cell Biology
Chromatography, High Pressure Liquid
Dipeptides - pharmacology
High-performance liquid chromatography
Hydrolysis
Internal Medicine
L-Proline
Laboratory Medicine
Mass Spectrometry
Mass spectroscopy
Metabolism
Metabolites
Neuroprotective Agents - pharmacology
Pathology
Phenylacetic acid
Physiological aspects
Proline
Rats
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Zusammenfassung:Metabolism of a new neuroprotector GZK-111 ( N -phenylacetylglycyl- L -proline ethyl ester) in rat blood plasma was studied by HPLC-mass spectrometry. Four biotransformation products were identified. It is concluded that the main ways of GZK-111 biotransformation are hydrolysis of the ester bond by esterases followed by degradation of the resulting metabolite, as well as reactions leading to the formation of phenylacetic acid and cycloprolylglycine that exhibits neuropsychotropic activity.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-022-05440-3