Advanced glycation end-products and advanced oxidation protein products in schizophrenia

•Oxidative stress takes part to schizophrenia (SZ) development and worsening.•Oxidative and carbonyl stress lead to the permanent production of AGEs and AOPPs.•They amplify ROS production and pro-inflammatory cytokines.•Data suggest that they have a potential as oxidative stress markers for SZ.•Anti...

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Veröffentlicht in:Psychiatry research 2022-05, Vol.311, p.114527-114527, Article 114527
Hauptverfasser: Pandolfo, Gianluca, Genovese, Giovanni, Bruno, Antonio, Campolo, Domenica, Tigano, Valeria, Cristani, Mariateresa, Casciaro, Marco, Pioggia, Giovanni, Gangemi, Sebastiano
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container_end_page 114527
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container_start_page 114527
container_title Psychiatry research
container_volume 311
creator Pandolfo, Gianluca
Genovese, Giovanni
Bruno, Antonio
Campolo, Domenica
Tigano, Valeria
Cristani, Mariateresa
Casciaro, Marco
Pioggia, Giovanni
Gangemi, Sebastiano
description •Oxidative stress takes part to schizophrenia (SZ) development and worsening.•Oxidative and carbonyl stress lead to the permanent production of AGEs and AOPPs.•They amplify ROS production and pro-inflammatory cytokines.•Data suggest that they have a potential as oxidative stress markers for SZ.•Antioxidant nutraceuticals and lifestyle diminish oxidative stress SZ symptoms. Schizophrenia pathophysiology is still not well understood. Genetic factors involving biochemical systems are key players and oxidative stress takes part to the development and worsening of SZ. Oxidative stress led to the permanent production of oxidation products such as advanced glycation end products (AGEs) and advanced oxidation protein products (AOPPs). These proteins interact with their receptor amplifying ROS production and pro-inflammatory cytokines sustaining a permanent loop. We tested plasma levels of AGEs and AOPPs in 30 SZ patients. Their levels were statistically higher than controls confirming their involvement in mental disorders. Antioxidant nutraceuticals and a healthy lifestyle could diminish oxidative stress and ameliorate SZ symptoms.
doi_str_mv 10.1016/j.psychres.2022.114527
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subjects Advanced Oxidation Protein Products
Antioxidants
Biomarkers
Glycation End Products, Advanced - metabolism
Humans
Oxidative Stress
Schizophrenia
title Advanced glycation end-products and advanced oxidation protein products in schizophrenia
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