Advanced glycation end-products and advanced oxidation protein products in schizophrenia

•Oxidative stress takes part to schizophrenia (SZ) development and worsening.•Oxidative and carbonyl stress lead to the permanent production of AGEs and AOPPs.•They amplify ROS production and pro-inflammatory cytokines.•Data suggest that they have a potential as oxidative stress markers for SZ.•Antioxidant nutraceuticals and lifestyle diminish oxidative stress SZ symptoms. Schizophrenia pathophysiology is still not well understood. Genetic factors involving biochemical systems are key players and oxidative stress takes part to the development and worsening of SZ. Oxidative stress led to the permanent production of oxidation products such as advanced glycation end products (AGEs) and advanced oxidation protein products (AOPPs). These proteins interact with their receptor amplifying ROS production and pro-inflammatory cytokines sustaining a permanent loop. We tested plasma levels of AGEs and AOPPs in 30 SZ patients. Their levels were statistically higher than controls confirming their involvement in mental disorders. Antioxidant nutraceuticals and a healthy lifestyle could diminish oxidative stress and ameliorate SZ symptoms.