Detection of hemoglobin Kinshasa by a capillary electrophoresis method

Detection of hemoglobin Kinshasa by a capillary electrophoresis method

•Hemoglobin Kinshasa is a rare mutation affecting the stop codon of the α2 gene (c.428A > T)•Hemoglobin Kinshasa can be detected by capillary electrophoresis of hemoglobin.•HbA1 and HbA2 hemoglobin variant are important to detect because they can lead to hemoglobin H disease if associated with an...

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Veröffentlicht in:Clinica chimica acta 2022-06, Vol.531, p.81-83
Hauptverfasser: Deltombe, Matthieu, Benamour, Meryem, Derclaye, Isabelle, Maisin, Diane
Format: Artikel
Sprache:eng
Schlagworte:
Capillary electrophoresis
Hemoglobin
Hemoglobinopathy
Kinshasa
α-Thalassemia
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Zusammenfassung:•Hemoglobin Kinshasa is a rare mutation affecting the stop codon of the α2 gene (c.428A > T)•Hemoglobin Kinshasa can be detected by capillary electrophoresis of hemoglobin.•HbA1 and HbA2 hemoglobin variant are important to detect because they can lead to hemoglobin H disease if associated with an α0-thalassemia carrier.
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2022.03.020