Chaperonin-containing tailless complex polypeptide 1 subunit 6A links with aggravating tumor features and disease-free survival in surgical gastric cancer patients: A long-term follow-up study
•CCT6A was increased in gastric cancer tissues validated by both IHC and RT-qPCR.•CCT6A correlated with advanced T stage and TNM stage in gastric cancer patients.•CCT6A linked with poor DFS reflected by K-M curve and multivariate Cox's analyses.•CCT6A showed a trend to relate to poor OS while l...
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| Veröffentlicht in: | Clinics and research in hepatology and gastroenterology 2022-08, Vol.46 (7), p.101913-101913, Article 101913 |
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| container_title | Clinics and research in hepatology and gastroenterology |
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| creator | He, Tingbang Yu, Deguo Wang, Zhenfeng Guo, Changcai Chang, Yong Wang, Dapeng |
| description | •CCT6A was increased in gastric cancer tissues validated by both IHC and RT-qPCR.•CCT6A correlated with advanced T stage and TNM stage in gastric cancer patients.•CCT6A linked with poor DFS reflected by K-M curve and multivariate Cox's analyses.•CCT6A showed a trend to relate to poor OS while lacked statistical significance.
Chaperonin-containing tailless complex polypeptide 1 subunit 6A (CCT6A) promotes several gastrointestinal-cancer malignant behaviors, while its clinical value in surgical gastric cancer is not clear. Hence, we aimed to investigate this issue.
Totally, tumor and adjacent specimens from 262 surgical gastric cancer patients were collected for measuring CCT6A protein level by immunohistochemistry (IHC) staining; meanwhile, specimens from 109 patients were used for evaluating CCT6A mRNA expression by reverse transcription-quantitative polymerase chain reaction (RT-qPCR).
CCT6A IHC score and CCT6A mRNA expression were upregulated in the tumor tissue compared with the adjacent tissue (both P |
| doi_str_mv | 10.1016/j.clinre.2022.101913 |
| format | Article |
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Chaperonin-containing tailless complex polypeptide 1 subunit 6A (CCT6A) promotes several gastrointestinal-cancer malignant behaviors, while its clinical value in surgical gastric cancer is not clear. Hence, we aimed to investigate this issue.
Totally, tumor and adjacent specimens from 262 surgical gastric cancer patients were collected for measuring CCT6A protein level by immunohistochemistry (IHC) staining; meanwhile, specimens from 109 patients were used for evaluating CCT6A mRNA expression by reverse transcription-quantitative polymerase chain reaction (RT-qPCR).
CCT6A IHC score and CCT6A mRNA expression were upregulated in the tumor tissue compared with the adjacent tissue (both P<0.001). Besides, elevated CCT6A IHC score was correlated with larger tumor size (P<0.001), advanced T stage (P=0.001), N stage (P=0.003) and tumor node metastasis (TNM) stage (P=0.001). Meanwhile, increased CCT6A mRNA expression was associated with higher T stage (P=0.008) and TNM stage (P=0.020). Besides, CCT6A protein high (P=0.017) and CCT6A mRNA high (P=0.047) were correlated with unfavorable disease-free survival (DFS), whereas neither CCT6A protein nor CCT6A mRNA expression was related to the overall survival (OS) (both P>0.05). Additionally, the multivariable Cox's proportional hazards regression analysis revealed that CCT6A protein high was independently correlated with shorter DFS (adjusted hazard ratio (HR): 2.032, P=0.005), but not with OS.
CCT6A is upregulated with its overexpression linking with advanced T stage, TNM stage and unfavorable DFS in surgical gastric cancer patients.</description><identifier>ISSN: 2210-7401</identifier><identifier>EISSN: 2210-741X</identifier><identifier>DOI: 10.1016/j.clinre.2022.101913</identifier><identifier>PMID: 35346891</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Biomarkers, Tumor - metabolism ; Chaperonin Containing TCP-1 - genetics ; Chaperonin Containing TCP-1 - metabolism ; Chaperonin-containing tailless complex polypeptide 1 subunit 6A ; Chaperonins ; Disease-Free Survival ; Follow-Up Studies ; Gastric cancer ; Humans ; Peptides ; Prognosis ; RNA, Messenger ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - pathology ; Stomach Neoplasms - surgery ; Tumor node metastasis stage ; verall survival</subject><ispartof>Clinics and research in hepatology and gastroenterology, 2022-08, Vol.46 (7), p.101913-101913, Article 101913</ispartof><rights>2022</rights><rights>Copyright © 2022. Published by Elsevier Masson SAS.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-8707577347bc888814e4616797ec1807f1001d5bfc76ec66bfdf1f7bc5057063</citedby><cites>FETCH-LOGICAL-c362t-8707577347bc888814e4616797ec1807f1001d5bfc76ec66bfdf1f7bc5057063</cites><orcidid>0000-0001-7013-3464</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clinre.2022.101913$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35346891$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>He, Tingbang</creatorcontrib><creatorcontrib>Yu, Deguo</creatorcontrib><creatorcontrib>Wang, Zhenfeng</creatorcontrib><creatorcontrib>Guo, Changcai</creatorcontrib><creatorcontrib>Chang, Yong</creatorcontrib><creatorcontrib>Wang, Dapeng</creatorcontrib><title>Chaperonin-containing tailless complex polypeptide 1 subunit 6A links with aggravating tumor features and disease-free survival in surgical gastric cancer patients: A long-term follow-up study</title><title>Clinics and research in hepatology and gastroenterology</title><addtitle>Clin Res Hepatol Gastroenterol</addtitle><description>•CCT6A was increased in gastric cancer tissues validated by both IHC and RT-qPCR.•CCT6A correlated with advanced T stage and TNM stage in gastric cancer patients.•CCT6A linked with poor DFS reflected by K-M curve and multivariate Cox's analyses.•CCT6A showed a trend to relate to poor OS while lacked statistical significance.
Chaperonin-containing tailless complex polypeptide 1 subunit 6A (CCT6A) promotes several gastrointestinal-cancer malignant behaviors, while its clinical value in surgical gastric cancer is not clear. Hence, we aimed to investigate this issue.
Totally, tumor and adjacent specimens from 262 surgical gastric cancer patients were collected for measuring CCT6A protein level by immunohistochemistry (IHC) staining; meanwhile, specimens from 109 patients were used for evaluating CCT6A mRNA expression by reverse transcription-quantitative polymerase chain reaction (RT-qPCR).
CCT6A IHC score and CCT6A mRNA expression were upregulated in the tumor tissue compared with the adjacent tissue (both P<0.001). Besides, elevated CCT6A IHC score was correlated with larger tumor size (P<0.001), advanced T stage (P=0.001), N stage (P=0.003) and tumor node metastasis (TNM) stage (P=0.001). Meanwhile, increased CCT6A mRNA expression was associated with higher T stage (P=0.008) and TNM stage (P=0.020). Besides, CCT6A protein high (P=0.017) and CCT6A mRNA high (P=0.047) were correlated with unfavorable disease-free survival (DFS), whereas neither CCT6A protein nor CCT6A mRNA expression was related to the overall survival (OS) (both P>0.05). Additionally, the multivariable Cox's proportional hazards regression analysis revealed that CCT6A protein high was independently correlated with shorter DFS (adjusted hazard ratio (HR): 2.032, P=0.005), but not with OS.
CCT6A is upregulated with its overexpression linking with advanced T stage, TNM stage and unfavorable DFS in surgical gastric cancer patients.</description><subject>Biomarkers, Tumor - metabolism</subject><subject>Chaperonin Containing TCP-1 - genetics</subject><subject>Chaperonin Containing TCP-1 - metabolism</subject><subject>Chaperonin-containing tailless complex polypeptide 1 subunit 6A</subject><subject>Chaperonins</subject><subject>Disease-Free Survival</subject><subject>Follow-Up Studies</subject><subject>Gastric cancer</subject><subject>Humans</subject><subject>Peptides</subject><subject>Prognosis</subject><subject>RNA, Messenger</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - surgery</subject><subject>Tumor node metastasis stage</subject><subject>verall survival</subject><issn>2210-7401</issn><issn>2210-741X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1v1DAQjRCIVqX_ACEfuWSxE8fe5YBUrfiSKnHpgZvlOOPUi2MHj7Nl_x0_DS8pPTKXebLevOeZV1WvGd0wysS7w8Z4FxJsGto056cda59Vl03DaC05-_78CVN2UV0jHmgp3tGtZC-ri7Zrudju2GX1e3-vZ0gxuFCbGLJ2BY2kdO8BkZg4zR5-kTn60wxzdgMQRnDpl-AyETekfOMHkgeX74kex6SPOv8VWKaYiAWdlwRIdBjI4BA0Qm0TQFFIR3fUnrhwxqMzBY8ac3KGGB0MJDIXKQgZ35NiE8NYZ0gTsdH7-FAvM8G8DKdX1QurPcL1Y7-q7j59vNt_qW-_ff66v7mtTSuaXG8llZ2ULZe92ZZiHLhgQu4kGLal0jJK2dD11kgBRojeDpbZQu5oJ6lor6q3q-yc4s8FMKvJoQHvdYC4oGoE5zveNS0rVL5STYqICayak5t0OilG1Tk9dVBreuqcnlrTK2NvHh2WfoLhaehfVoXwYSVAWfPoICk05T4GBpfAZDVE93-HP_SesSE</recordid><startdate>202208</startdate><enddate>202208</enddate><creator>He, Tingbang</creator><creator>Yu, Deguo</creator><creator>Wang, Zhenfeng</creator><creator>Guo, Changcai</creator><creator>Chang, Yong</creator><creator>Wang, Dapeng</creator><general>Elsevier Masson SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7013-3464</orcidid></search><sort><creationdate>202208</creationdate><title>Chaperonin-containing tailless complex polypeptide 1 subunit 6A links with aggravating tumor features and disease-free survival in surgical gastric cancer patients: A long-term follow-up study</title><author>He, Tingbang ; Yu, Deguo ; Wang, Zhenfeng ; Guo, Changcai ; Chang, Yong ; Wang, Dapeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-8707577347bc888814e4616797ec1807f1001d5bfc76ec66bfdf1f7bc5057063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biomarkers, Tumor - metabolism</topic><topic>Chaperonin Containing TCP-1 - genetics</topic><topic>Chaperonin Containing TCP-1 - metabolism</topic><topic>Chaperonin-containing tailless complex polypeptide 1 subunit 6A</topic><topic>Chaperonins</topic><topic>Disease-Free Survival</topic><topic>Follow-Up Studies</topic><topic>Gastric cancer</topic><topic>Humans</topic><topic>Peptides</topic><topic>Prognosis</topic><topic>RNA, Messenger</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach Neoplasms - surgery</topic><topic>Tumor node metastasis stage</topic><topic>verall survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Tingbang</creatorcontrib><creatorcontrib>Yu, Deguo</creatorcontrib><creatorcontrib>Wang, Zhenfeng</creatorcontrib><creatorcontrib>Guo, Changcai</creatorcontrib><creatorcontrib>Chang, Yong</creatorcontrib><creatorcontrib>Wang, Dapeng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinics and research in hepatology and gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Tingbang</au><au>Yu, Deguo</au><au>Wang, Zhenfeng</au><au>Guo, Changcai</au><au>Chang, Yong</au><au>Wang, Dapeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chaperonin-containing tailless complex polypeptide 1 subunit 6A links with aggravating tumor features and disease-free survival in surgical gastric cancer patients: A long-term follow-up study</atitle><jtitle>Clinics and research in hepatology and gastroenterology</jtitle><addtitle>Clin Res Hepatol Gastroenterol</addtitle><date>2022-08</date><risdate>2022</risdate><volume>46</volume><issue>7</issue><spage>101913</spage><epage>101913</epage><pages>101913-101913</pages><artnum>101913</artnum><issn>2210-7401</issn><eissn>2210-741X</eissn><abstract>•CCT6A was increased in gastric cancer tissues validated by both IHC and RT-qPCR.•CCT6A correlated with advanced T stage and TNM stage in gastric cancer patients.•CCT6A linked with poor DFS reflected by K-M curve and multivariate Cox's analyses.•CCT6A showed a trend to relate to poor OS while lacked statistical significance.
Chaperonin-containing tailless complex polypeptide 1 subunit 6A (CCT6A) promotes several gastrointestinal-cancer malignant behaviors, while its clinical value in surgical gastric cancer is not clear. Hence, we aimed to investigate this issue.
Totally, tumor and adjacent specimens from 262 surgical gastric cancer patients were collected for measuring CCT6A protein level by immunohistochemistry (IHC) staining; meanwhile, specimens from 109 patients were used for evaluating CCT6A mRNA expression by reverse transcription-quantitative polymerase chain reaction (RT-qPCR).
CCT6A IHC score and CCT6A mRNA expression were upregulated in the tumor tissue compared with the adjacent tissue (both P<0.001). Besides, elevated CCT6A IHC score was correlated with larger tumor size (P<0.001), advanced T stage (P=0.001), N stage (P=0.003) and tumor node metastasis (TNM) stage (P=0.001). Meanwhile, increased CCT6A mRNA expression was associated with higher T stage (P=0.008) and TNM stage (P=0.020). Besides, CCT6A protein high (P=0.017) and CCT6A mRNA high (P=0.047) were correlated with unfavorable disease-free survival (DFS), whereas neither CCT6A protein nor CCT6A mRNA expression was related to the overall survival (OS) (both P>0.05). Additionally, the multivariable Cox's proportional hazards regression analysis revealed that CCT6A protein high was independently correlated with shorter DFS (adjusted hazard ratio (HR): 2.032, P=0.005), but not with OS.
CCT6A is upregulated with its overexpression linking with advanced T stage, TNM stage and unfavorable DFS in surgical gastric cancer patients.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>35346891</pmid><doi>10.1016/j.clinre.2022.101913</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-7013-3464</orcidid></addata></record> |
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| ispartof | Clinics and research in hepatology and gastroenterology, 2022-08, Vol.46 (7), p.101913-101913, Article 101913 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Biomarkers, Tumor - metabolism Chaperonin Containing TCP-1 - genetics Chaperonin Containing TCP-1 - metabolism Chaperonin-containing tailless complex polypeptide 1 subunit 6A Chaperonins Disease-Free Survival Follow-Up Studies Gastric cancer Humans Peptides Prognosis RNA, Messenger Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Stomach Neoplasms - surgery Tumor node metastasis stage verall survival |
| title | Chaperonin-containing tailless complex polypeptide 1 subunit 6A links with aggravating tumor features and disease-free survival in surgical gastric cancer patients: A long-term follow-up study |
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