Extended pelvic resection for gynecological malignancies: A review of out-of-the-box surgery

The term ‘out-of-the-box surgery’ in gynecologic oncology was recently coined to describe the resection of tumor growing out of the endopelvic cavity. In the specific case of pelvic sidewall involvement, a laterally extended pelvic resection may be required. As previously defined by Höckel, this resection requires the en bloc removal of structures including the pelvic sidewall muscles, bones, nerves, and/or major vessels. This complex radical procedure leads to tumor-free margins in more than 75% of the patients, with reliable functional results. The rate of recurrence and overall survival are directly correlated with clear resection margins. Progress in imaging, surgical techniques, and perioperative care currently offer the opportunity to attempt surgical curative resection in selected patients for whom palliative therapy was the only alternative. However, the procedure is associated with a high rate of major postoperative complications affecting up to 60% of patients. Multidisciplinary expert centers are the most likely to achieve this complex surgery with favorable oncological outcomes. The aim of this review is to summarize the key issues of out-of-the-box surgery in gynecologic cancer. •The term ‘out-of-the-box surgery’ is employed for the resection of tumor growing out of the endopelvic cavity.•The rate of recurrence and overall survival are directly correlated with clear resection margin status.•In selected patients, tumor-free margins may be obtained in more than 75% of the cases.•This ultraradical surgery is associated with major postoperative complications affecting up to 60% of patients.•Multidisciplinary expert centers are the most likely to achieve optimal oncological outcomes.