Synthesis and characterization of photosensitive gelatin-based hydrogels for photodynamic therapy in HeLa-CCL2 cell line

Synthesis and characterization of photosensitive gelatin-based hydrogels for photodynamic therapy in HeLa-CCL2 cell line

•A nanohydrogel system, encapsulated with chloroaluminium phthalocyanine (ClAlPc), was synthesized Using gelatin as based polymer by the chemical cross-linking technique.•SEM analysis showed the presence of three-dimensional networks in the formulation.•The loading efficiency was 70%.•The results of...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Photodiagnosis and photodynamic therapy 2022-06, Vol.38, p.102818-102818, Article 102818
Hauptverfasser: Ambrósio, Jéssica A.R., Pinto, Bruna C.S., Marmo, Vitor Luca Moura, Santos, Kennedy Wallace dos, Junior, Milton Beltrame, Pinto, Juliana G., Ferreira-Strixino, Juliana, Raniero, Leandro José, Simioni, Andreza R.
Format: Artikel
Sprache:eng
Schlagworte:
Chloroaluminium phthalocyanine
drug delivery
Gelatin
HeLa Cells
Humans
Hydrogel
Hydrogels
Indoles
Photochemotherapy - methods
Photodynamic therapy
Photosensitizing Agents - chemistry
Photosensitizing Agents - pharmacology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:•A nanohydrogel system, encapsulated with chloroaluminium phthalocyanine (ClAlPc), was synthesized Using gelatin as based polymer by the chemical cross-linking technique.•SEM analysis showed the presence of three-dimensional networks in the formulation.•The loading efficiency was 70%.•The results of trypan blue exclusion test have shown significant reduction (p 
ISSN:1572-1000
1873-1597
DOI:10.1016/j.pdpdt.2022.102818