Avoiding kidney damage in ICU sedation with sevoflurane: use isoflurane instead

Avoiding kidney damage in ICU sedation with sevoflurane: use isoflurane instead

Intensive care unit (ICU) sedation with sevoflurane is associated with nephrogenic diabetes insipidus. Given that isoflurane is now licenced (in Europe) for ICU sedation and has Investigational New Drug status in the USA, evidence indicates that clinicians should stop using sevoflurane in this indic...

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Veröffentlicht in:British journal of anaesthesia : BJA 2022-07, Vol.129 (1), p.7-10
1. Verfasser: Sneyd, J. Robert
Format: Artikel
Sprache:eng
Schlagworte:
acute kidney injury
diabetes insipidus
isoflurane
nephrotoxicity
sedation
sevoflurane
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Zusammenfassung:Intensive care unit (ICU) sedation with sevoflurane is associated with nephrogenic diabetes insipidus. Given that isoflurane is now licenced (in Europe) for ICU sedation and has Investigational New Drug status in the USA, evidence indicates that clinicians should stop using sevoflurane in this indication except in the context of clinical trials.
ISSN:0007-0912
1471-6771
DOI:10.1016/j.bja.2022.02.031