New therapy strategies in the management of breast cancer

•Breast cancer (BC) is the most common cancer in women worldwide.•Several signaling pathways are under investigation as new drug targets in BC.•lncRNAs and miRNAs are promising advanced targets in BC managements. Breast cancer (BC), the second leading cause of cancer-related deaths after lung cancer, is the most common cancer type among women worldwide. BC comprises multiple subtypes based on molecular properties. Depending on the type of BC, hormone therapy, targeted therapy, and immunotherapy are the current systemic treatment options along with conventional chemotherapy. Several new molecular targets, miRNAs, and long non-coding RNAs (lncRNAs), have been discovered over the past few decades and are powerful potential therapeutic targets. Here, we review advanced therapeutics as new players in BC management.