Systemic Abscopal Effect of Low-dose Radiotherapy (2 Gy ×2) against Palatine Tonsil Follicular Lymphoma

Systemic Abscopal Effect of Low-dose Radiotherapy (2 Gy ×2) against Palatine Tonsil Follicular Lymphoma

A 52-year-old man presented with palatine tonsillar swelling caused by follicular lymphoma. His tumor burden was low, but exacerbation of snoring and dysphagia was observed. Considering the first wave of coronavirus disease 2019 (COVID-19) pandemic, he received palliative 4-Gy irradiation to the ton...

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Veröffentlicht in:Internal Medicine 2022/10/15, Vol.61(20), pp.3107-3110
Hauptverfasser: Togitani, Kazuto, Asagiri, Tadashi, Iguchi, Mitsuko, Igawa, Takuro, Yoshino, Tadashi, Kojima, Kensuke
Format: Artikel
Sprache:eng
Schlagworte:
abscopal effect
CD5
Coronaviruses
COVID-19
Dysphagia
follicular lymphoma
Immunotherapy
Internal medicine
low-dose radiotherapy
Lymphoma
Radiation therapy
Tonsil
Tumors
Vaccination
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Beschreibung
Zusammenfassung:A 52-year-old man presented with palatine tonsillar swelling caused by follicular lymphoma. His tumor burden was low, but exacerbation of snoring and dysphagia was observed. Considering the first wave of coronavirus disease 2019 (COVID-19) pandemic, he received palliative 4-Gy irradiation to the tonsils in 2 fractions, which induced partial regression of tonsillar swellings and eradication of the circulating lymphoma cells. We suggest that low-dose radiotherapy triggered an abscopal effect of lymphoma, which allowed the patient time to receive COVID-19 vaccination before starting immunosuppressive chemo-immunotherapy.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.8968-21