What Are the Risk Factors for Epilepsy Among Patients With Craniosynostosis?

The purpose of this study was to determine the risk factors for epilepsy among patients with craniosynostosis. This is a retrospective cohort study that was completed with the Kids' Inpatient Database. All patients diagnosed with craniosynostosis between the years 2000 and 2012 were included. The primary predictor variables were obstructive sleep apnea (OSA), hydrocephalus, brain compression (BC), cerebral edema, papilledema, dolichocephaly, and plagiocephaly. The outcome variable was epilepsy. Logistic regression analysis was used to determine odds ratios (ORs) for the outcome (epilepsy). Our final sample had 4,709 patients with craniosynostosis, of whom 244 patients exhibited epilepsy (5.2%). The mean age of the patients was 1.43 years (range: 0-20). Relative to Asian patients, Black patients were 4 times more likely to have epilepsy (P