Targeted Manipulation of Cellular RNA m6A Methylation at the Single-Base Level

Development of tools for precise manipulation of cellular mRNA m6A methylation at the base level is highly required. Here, we report an RNA-guided RNA modification strategy using a fusion protein containing deactivated nuclease Cas13b and m6A methyltransferase METTL14, namely, dCas13b-M14, which is...

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Veröffentlicht in:	ACS chemical biology 2022-04, Vol.17 (4), p.854-863
Hauptverfasser:	Gao, Minsong, Su, Shichen, Cao, Jie, Xiang, Siying, Huang, Ye, Shu, Xiao, Ma, Jinbiao, Liu, Jianzhao
Format:	Artikel
Sprache:	eng ; jpn
Online-Zugang:	Volltext
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