Biomembrane‐mimetic hemoperfusion adsorbent for efficient removal of low‐density lipoprotein from hyperlipemia blood

Lowering of low‐density lipoprotein (LDL) levels in blood of patients with hyperlipidaemia can effectively prevent the progression of atherosclerosis and coronary heart disease. The present study demonstrated a facile synthesis strategy to prepare biomembrane‐mimetic LDL adsorbent (PVA@COOH‐PE) via directional immobilization of phospholipid onto macro‐porous cross‐linked poly(vinyl alcohol) spheres. The binding between the prepared adsorbent and LDL particles simulates the cytosolic lipid droplets to form a lipid‐packing structure. The adsorbent possesses satisfactory removal efficiency for LDL and total cholesterol (TCH) in hyperlipemia serum, while remains high‐density lipoprotein (HDL) concentration within the normal range. The adsorption capacities for LDL and TCH are about 1.13 and 1.74 mg/ml respectively, which are nearly three and four times higher than that of HDL (0.42 mg/ml). The adsorbent also possesses satisfactory anticoagulant properties, causes negligible effect on blood cells and produces low hemolysis ratios. The excellent blood compatibility plus LDL removal efficiency of PVA@COOH‐PE indicates its good application prospect as hemoperfusion adsorbent in the treatment of hyperlipidaemia.