Synthetic mRNA for ex vivo therapeutic applications

Synthetic mRNA for ex vivo therapeutic applications

Synthetic mRNA is attracting much attention as a new drug modality. Now, there is great interest in the next applications of mRNA medicines, especially for therapeutic purposes of various diseases. Not only in vivo applicable mRNA medicines, there are many researches using ex vivo or in vitro mRNA t...

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Veröffentlicht in:Drug metabolism and pharmacokinetics 2022-06, Vol.44, p.100447-100447, Article 100447
Hauptverfasser: Nakanishi, Hideyuki, Itaka, Keiji
Format: Artikel
Sprache:eng
Schlagworte:
Cell engineering
Genome editing
Messenger RNA (mRNA)
mRNA medicine
Reprogramming
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Zusammenfassung:Synthetic mRNA is attracting much attention as a new drug modality. Now, there is great interest in the next applications of mRNA medicines, especially for therapeutic purposes of various diseases. Not only in vivo applicable mRNA medicines, there are many researches using ex vivo or in vitro mRNA transfection, some of which are already used in the preclinical or clinical settings. In this short article, the ex vivo mRNA applications are reviewed, in the hope of providing insight to develop future mRNA medicines.
ISSN:1347-4367
1880-0920
DOI:10.1016/j.dmpk.2022.100447