Shorter Treatment for Nonsevere Tuberculosis in African and Indian Children

Completing 6 months of treatment for tuberculosis in children is a challenge. In this open-label trial involving 1204 children in sub-Saharan Africa and India, 4 months of antituberculosis therapy was noninferior to 6 months of therapy.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2022-03, Vol.386 (10), p.911-922
Hauptverfasser:	Turkova, Anna, Wills, Genevieve H., Wobudeya, Eric, Chabala, Chishala, Palmer, Megan, Kinikar, Aarti, Hissar, Syed, Choo, Louise, Musoke, Philippa, Mulenga, Veronica, Mave, Vidya, Joseph, Bency, LeBeau, Kristen, Thomason, Margaret J., Mboizi, Robert B., Kapasa, Monica, van der Zalm, Marieke M., Raichur, Priyanka, Bhavani, Perumal K., McIlleron, Helen, Demers, Anne-Marie, Aarnoutse, Rob, Love-Koh, James, Seddon, James A., Welch, Steven B., Graham, Stephen M., Hesseling, Anneke C., Gibb, Diana M., Crook, Angela M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adults Adverse events Africa Airway management Antitubercular Agents - administration & dosage Bacterial infections Caregivers Child Child, Preschool Childhood Diseases Children Diagnostics Drug Administration Schedule Drug dosages Drug resistance Drug Therapy, Combination Female Global Health HIV Human immunodeficiency virus Humans India Infant Infections Infectious Disease Intention to Treat Analysis Isoniazid - administration & dosage Laboratories Male Medical diagnosis Medical research Patient Acuity Pediatrics Population Pyrazinamide - administration & dosage Rifampin - administration & dosage Software Statistical analysis Treatment Outcome Tuberculosis Tuberculosis - drug therapy
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Beschreibung
Zusammenfassung:	Completing 6 months of treatment for tuberculosis in children is a challenge. In this open-label trial involving 1204 children in sub-Saharan Africa and India, 4 months of antituberculosis therapy was noninferior to 6 months of therapy.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2104535