Impaired gut barrier affects microglia health

As researchers uncover new roles for the microbiome in health and disease, recent studies have emerged linking the microbiome to aspects of aging. Mossad and colleagues demonstrate that a microbiome-mediated disruption of the intestinal barrier, associated with aging, can contribute to dysfunction o...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature neuroscience 2022-03, Vol.25 (3), p.268-270
Hauptverfasser:	Bostick, John W., Mazmanian, Sarkis K.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326 631/378/371 64/60 Age Aging Alzheimer's disease Animal Genetics and Genomics Bacteria Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Brain research Gene expression Metabolism Metabolites Microbiomes Microbiota Microglia Microorganisms Mitochondria Neurobiology Neurosciences News & Views news-and-views Oxidative stress Permeability Phosphatase
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	As researchers uncover new roles for the microbiome in health and disease, recent studies have emerged linking the microbiome to aspects of aging. Mossad and colleagues demonstrate that a microbiome-mediated disruption of the intestinal barrier, associated with aging, can contribute to dysfunction of microglia in mice.
ISSN:	1097-6256 1546-1726
DOI:	10.1038/s41593-022-01028-2