Dynamics of salivary human herpesvirus‐6 and ‐7 shedding in pregnant women

Reactivation of Betaherpesvirinae (Human herpesvirus 6A: HHV‐6A, ‐6B, HHV‐7) may be associated with mental illness and host fatigue. This study aimed to determine whether viral reactivation, measured by monitoring salivary viral DNA load, can be used to monitor depression in pregnant and postpartum...

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Veröffentlicht in:Journal of medical virology 2022-07, Vol.94 (7), p.3359-3367
Hauptverfasser: Suzuki, Noriko, Ihira, Masaru, Enya, Yasuko, Yumi, Takahashi, Izuru, Chisato, Rie, Igarashi, Higashimoto, Yuki, Hiroki, Miura, Asaki, Takanashi, Kaoru, Fujimoto, Kawamura, Yoshiki, Yoshikawa, Tetsushi
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Sprache:eng
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Zusammenfassung:Reactivation of Betaherpesvirinae (Human herpesvirus 6A: HHV‐6A, ‐6B, HHV‐7) may be associated with mental illness and host fatigue. This study aimed to determine whether viral reactivation, measured by monitoring salivary viral DNA load, can be used to monitor depression in pregnant and postpartum women. Saliva samples were collected from 64 pregnant women at five points of observation periods. The HHV‐6‐ and HHV‐7‐specific qPCRs were carried out to measure viral DNA load. When HHV‐6 DNA was detected in saliva, nested PCR was used to discriminate between HHV‐6A and ‐6B. In both viruses, a significant correlation was observed between detection frequency and viral DNA load in saliva. In the low‐shedding group, HHV‐6 DNA was significantly higher in the third trimester (p 
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.27692