Lack of association between 11 gene polymorphisms on weight loss 1 year after Roux‐en‐y gastric bypass surgery in woman

Background Although effective, the impact of bariatric surgery on weight loss is variable, and little is known about the influence of single‐nucleotide polymorphisms (SNPs). The present study investigated the association of eleven SNPs related to obesity with weight loss 1 year after Roux‐Y gastric bypass (RYGB) surgery in female patients. Methods This prospective study included 351 women with obesity. The genotypes for eleven SNPs (GHRL–rs26802; GHSR–rs572169; LEP–rs7799039; LEPR–rs1137101; 5HT2C–rs3813929; UCP2–rs659366; UCP3–rs1800849; SH2B1–rs7498665; TAS1R2–rs35874116; TAS1R2–rs9701796; FTO–rs9939609) were determined using a real‐time polymerase chain reaction and TaqMan assays. Anthropometric measurements were performed before and 1 year after RYGB surgery. To evaluate the factors that influenced the proportion of weight loss 1 year after surgery, beta regression analysis was used. The models were estimated using the GLIMMIX procedure in SAS statistical software. p