Coupling of Heteroaryl Halides with Chlorodifluoroacetamides and Chlorodifluoroacetate by Nickel Catalysis

A nickel‐catalyzed cross‐coupling of heteroaryl halides with chlorodifluoroacetamides and chlorodifluoroacetate has been developed. The combination of NiCl2 ⋅ DME with 4,4′‐diNon‐bpy, co‐ligand PPh3, and additive LiCl renders the catalytic system efficient for the synthesis of medicinal interest heteroaryldifluoroacetamides. The application of the method leads to short and highly efficient synthesis of biologically active molecules, providing a facile route for applications in medicinal chemistry and agrochemistry. A nickel‐catalyzed cross‐coupling of heteroaryl halides with chlorodifluoroacetamides and chlorodifluoroacetate has been developed. The synthetic simplicity from widely available fluorine sources and heteroaryl halides renders the protocol cost efficient synthesis of biologically active molecules, providing a facile route for applications in medicinal chemistry.