High-Sensitivity Troponin I after Cardiac Surgery and 30-Day Mortality

A prospective cohort study of 13,862 patients showed that among those who underwent isolated coronary-artery bypass grafting or aortic-valve replacement or repair, the threshold high-sensitivity cardiac troponin I level (within 1 day after surgery) associated with an adjusted hazard ratio for death...

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Veröffentlicht in:	The New England journal of medicine 2022-03, Vol.386 (9), p.827-836
Hauptverfasser:	Devereaux, P.J, Lamy, Andre, Chan, Matthew T.V, Allard, René V, Lomivorotov, Vladimir V, Landoni, Giovanni, Zheng, Hong, Paparella, Domenico, McGillion, Michael H, Belley-Côté, Emilie P, Parlow, Joel L, Underwood, Malcolm J, Wang, Chew Yin, Dvirnik, Nazari, Abubakirov, Marat, Fominskiy, Evgeny, Choi, Stephen, Fremes, Stephen, Monaco, Fabrizio, Urrútia, Gerard, Maestre, Marialuz, Hajjar, Ludhmila A, Hillis, Graham S, Mills, Nicholas L, Margari, Vito, Mills, Joseph D, Billing, J. Stephen, Methangkool, Emily, Polanczyk, Carisi A, Sant’Anna, Roberto, Shukevich, Dmitry, Conen, David, Kavsak, Peter A, McQueen, Matthew J, Brady, Katheryn, Spence, Jessica, Le Manach, Yannick, Mian, Rajibul, Lee, Shun Fu, Bangdiwala, Shrikant I, Hussain, Sara, Borges, Flavia K, Pettit, Shirley, Vincent, Jessica, Guyatt, Gordon H, Yusuf, Salim, Alpert, Joseph S, White, Harvey D, Whitlock, Richard P
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aortic Valve - surgery Biomarkers - blood Calcium-binding protein Cardiac Surgical Procedures - adverse effects Cardiac Surgical Procedures - mortality Cardiology Cardiology General Cardiovascular Surgery Consent Consortia Coronary Artery Bypass - adverse effects Coronary Disease Death Female Heart Heart attacks Heart surgery Humans Ischemia Laboratories Male Middle Aged Mortality Myocardial Infarction Myocardial Infarction - blood Myocardial Infarction - diagnosis Myocardial Infarction - etiology Myocardial Infarction - mortality Patients Postoperative Complications - blood Postoperative Complications - diagnosis Postoperative Complications - mortality Prospective Studies Reference Values Sample size Software Statistical analysis Surgery Troponin Troponin I Troponin I - blood Variables
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Beschreibung
Zusammenfassung:	A prospective cohort study of 13,862 patients showed that among those who underwent isolated coronary-artery bypass grafting or aortic-valve replacement or repair, the threshold high-sensitivity cardiac troponin I level (within 1 day after surgery) associated with an adjusted hazard ratio for death within 30 days of more than 1.00 was 5670 ng per liter — 218 times the upper reference limit.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2000803