Exploration of Dipeptidyl Peptidase-IV (DPP-IV) Inhibitory Peptides from Silkworm Pupae (Bombyx mori) Proteins Based on In Silico and In Vitro Assessments

Exploration of Dipeptidyl Peptidase-IV (DPP-IV) Inhibitory Peptides from Silkworm Pupae (Bombyx mori) Proteins Based on In Silico and In Vitro Assessments

This study aimed at exploring dipeptidyl peptidase-IV (DPP-IV) inhibitory peptides from silkworm pupae proteins by in silico analysis and in vitro assessments. In silico analysis of 274 silkworm pupae proteomes indicated that DPP-IV inhibitory peptides can be released from silkworm pupae proteins. I...

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Veröffentlicht in:Journal of agricultural and food chemistry 2022-03, Vol.70 (12), p.3862-3871
Hauptverfasser: Luo, Fali, Fu, Yu, Ma, Liang, Dai, Hongjie, Wang, Hongxia, Chen, Hai, Zhu, Hankun, Yu, Yong, Hou, Yong, Zhang, Yuhao
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Bombyx - metabolism
Chromatography, Liquid
Dipeptidyl Peptidase 4 - chemistry
Dipeptidyl-Peptidase IV Inhibitors - chemistry
Dipeptidyl-Peptidase IV Inhibitors - pharmacology
Functional Structure/Activity Relationships
Molecular Docking Simulation
Peptides - chemistry
Pupa - metabolism
Tandem Mass Spectrometry
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Zusammenfassung:This study aimed at exploring dipeptidyl peptidase-IV (DPP-IV) inhibitory peptides from silkworm pupae proteins by in silico analysis and in vitro assessments. In silico analysis of 274 silkworm pupae proteomes indicated that DPP-IV inhibitory peptides can be released from silkworm pupae proteins. In vitro assessments revealed that pepsin and bromelain led to better production of DPP-IV inhibitory peptides from silkworm pupae protein. Notably, peptide fractions (
ISSN:0021-8561
1520-5118
DOI:10.1021/acs.jafc.1c08225