Interleukin-38 in Health and Disease

Interleukin-38 in Health and Disease

•IL-38 is a member of the IL-1 Family that inhibits IL-1R6, IL-1R9, and IL-1R1 signaling.•IL-38 inhibits the innate, trained, and adaptive immune response.•IL-38 polymorphisms are associated with inflammatory disease and biomarkers thereof.•IL-38 is often indicative of human disease severity, and ge...

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Veröffentlicht in:Cytokine (Philadelphia, Pa.) Pa.), 2022-04, Vol.152, p.155824-155824, Article 155824
Hauptverfasser: de Graaf, Dennis M., Teufel, Lisa U., Joosten, Leo A.B., Dinarello, Charles A.
Format: Artikel
Sprache:eng
Schlagworte:
IL-1
IL-1R6
IL-1R9
IL-36
IL-36R
IL-38
IL1RAPL1
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Zusammenfassung:•IL-38 is a member of the IL-1 Family that inhibits IL-1R6, IL-1R9, and IL-1R1 signaling.•IL-38 inhibits the innate, trained, and adaptive immune response.•IL-38 polymorphisms are associated with inflammatory disease and biomarkers thereof.•IL-38 is often indicative of human disease severity, and generally protective in animal models.•The role of B cells in the biology of IL-38 remains elusive.
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2022.155824