Mycobacterium genavense Central Nervous System Infection in a Patient with AIDS

Individuals with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) risk developing opportunistic infections including Mycobacterium tuberculosis complex (Mtbc) and organisms belonging to the Mycobacterium avium complex (MAC). MRI brain 10 days later demonstrated a reductio...

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Veröffentlicht in:Canadian journal of neurological sciences 2023-03, Vol.50 (2), p.305-307
Hauptverfasser: Kuczynski, Andrea M., Krajden, Sigmund, Spears, Julian, Kus, Julianne V., Munoz, David G., Ostrowski, Mario, Chen, Yan, Supala-Berger, Agnes
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Sprache:eng
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Zusammenfassung:Individuals with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) risk developing opportunistic infections including Mycobacterium tuberculosis complex (Mtbc) and organisms belonging to the Mycobacterium avium complex (MAC). MRI brain 10 days later demonstrated a reduction in mass size to 6 mm. Given atypical neuroimaging findings and negative serology, he was not started on Toxoplasmosis treatment. Direct PCR of biopsy material at 3 weeks post-craniotomy resulted in a 16S rRNA gene product (567 bp) with 99% match and hsp65 product (387 bp) with 100% match to M. genavense type strain 2289.
ISSN:0317-1671
2057-0155
DOI:10.1017/cjn.2022.6