Bisphosphonate of Zoledronate Has Antiapoptotic Effect on Hypoxia/Reoxygenation Injury in Human Embryonic Stem Cell-Derived Cardiomyocytes Through Trk Signaling Pathway

Bisphosphonate of Zoledronate Has Antiapoptotic Effect on Hypoxia/Reoxygenation Injury in Human Embryonic Stem Cell-Derived Cardiomyocytes Through Trk Signaling Pathway

In this work, we investigated the in vitro and in vivo functions of bisphosphonate of zoledronate (Zd) in hypoxia/reoxygenation (H/R) injured human embryonic stem cell-derived cardiomyocytes (hES-CMs). In the in vitro setting, the effects of Zd on hES-CM survival and differentiation were examined. W...

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Veröffentlicht in:Cell biochemistry and biophysics 2022-06, Vol.80 (2), p.435-442
Hauptverfasser: Wang, Hua, Zhao, Wen-Shu, Xu, Lin
Format: Artikel
Sprache:eng
Schlagworte:
Animal models
Animals
Apoptosis
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biotechnology
Bisphosphonates
Cadherins
Cardiomyocytes
Cardiovascular diseases
Cell Biology
Cell death
Coronary artery disease
Differentiation
Diphosphonates - metabolism
Diphosphonates - pharmacology
Embryo cells
Embryogenesis
Heart diseases
Human Embryonic Stem Cells - metabolism
Humans
Hypoxia
Hypoxia - metabolism
In vivo methods and tests
Injuries
Ischemia
Life Sciences
Myocardial infarction
Myocardial Reperfusion Injury - metabolism
Myocytes, Cardiac
Original Paper
Pharmacology/Toxicology
Phosphorylation
Signal Transduction
Stem cell transplantation
Stem cells
Survival
TrkA protein
Vascular endothelial growth factor
Zoledronic acid
Zoledronic Acid - metabolism
Zoledronic Acid - pharmacology
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Zusammenfassung:In this work, we investigated the in vitro and in vivo functions of bisphosphonate of zoledronate (Zd) in hypoxia/reoxygenation (H/R) injured human embryonic stem cell-derived cardiomyocytes (hES-CMs). In the in vitro setting, the effects of Zd on hES-CM survival and differentiation were examined. We found that low and medium concentrations (
ISSN:1085-9195
1559-0283
DOI:10.1007/s12013-021-01031-7