A novel treatment for malignant spasticity: The therapeutic use of stereotactic radiosurgery (SRS)

•Malignant spasticity is characterized by increased muscle contraction, also painful.•Drugs and surgery have sometimes complications in these frail patients.•SRS to the spinal roots can be a non-invasive way to treat malignant spasticity.•3 patients treated with SRS reported a clinical benefit with no acute toxicity. Spasticity is a clinical condition secondary to central nervous system damage, which impairs patients’ mobility and quality of life. Stereotactic radiosurgery (SRS) to the spinal roots responsible of the spasms might represent a non-invasive therapy. The present are the preliminary results of the first clinical use of this novel technique.