Clostridioides difficile from Brazilian hospitals: characterization of virulence genes by whole genome sequencing

Clostridioides difficile from Brazilian hospitals: characterization of virulence genes by whole genome sequencing

Clostridioides difficile (CD) is the most frequent cause of healthcare related diarrhea and its severity has increased in the last decade by the spread of hypervirulent strains. Most important CD virulence factor is toxin production; however, not only toxins are responsible for Clostridioides virule...

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Veröffentlicht in:Microbes and infection 2022-07, Vol.24 (5), p.104953-104953, Article 104953
Hauptverfasser: Rizek, Camila Fonseca, Martins, Roberta Cristina, Girão, Evelyne Santana, Tavares, Bruno de Melo, dos Santos, Sania Alves, Gamarra, Gessica Lorena, Perdigão Neto, Lauro Vieira, Diogo, Constancia, Orsi, Tatiana D' Annibale, Boszczowski, Icaro, Piastrelli, Filipe, Costa, Cecilia Leite, Costa, Daniely Viana, Maciel, Geovania, Romão, Janete, Brito, Gerly Anne de Castro, Costa, Silvia Figueiredo
Format: Artikel
Sprache:eng
Schlagworte:
Clostridioides difficile
Toxins
Virulence
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Zusammenfassung:Clostridioides difficile (CD) is the most frequent cause of healthcare related diarrhea and its severity has increased in the last decade by the spread of hypervirulent strains. Most important CD virulence factor is toxin production; however, not only toxins are responsible for Clostridioides virulence. We sequenced 38 strains and analyzed the presence and integrity of 24 virulence (including toxin) genes. We identified 28 toxigenic strains, six also presented the cdt genes. Only six strains didn't present all others genes searched. All absent genes were adhesion related. Understand others CD virulence factors can lead to a best understanding on this matter.
ISSN:1286-4579
1769-714X
DOI:10.1016/j.micinf.2022.104953