Case 6-2022: A 68-Year-Old Man with Fatigue, Weight Loss, and Hyperglycemia

A 68-year-old man with metastatic melanoma was evaluated in the oncology clinic because of fatigue and weight loss. Hypothyroidism had been noted 4 months earlier; increased thirst and nocturia had developed 2 weeks earlier. The blood glucose level was 505 mg per deciliter (reference range, 70 to 11...

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Veröffentlicht in:	The New England journal of medicine 2022-02, Vol.386 (8), p.781-787
Hauptverfasser:	Wing, Jonathan R, Kimball, Allison, Rengarajan, Michelle
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antibodies, Monoclonal, Humanized - adverse effects Autoimmune diseases Biopsy Brain Neoplasms - drug therapy Brain Neoplasms - secondary Cardiovascular disease Case reports Clinical Medicine Clinical Medicine General Diabetes Diabetes Mellitus - chemically induced Diabetes Mellitus - diagnosis Diagnosis, Differential Emergency Medicine Emergency Medicine General Endocrinology Family medical history Fatigue Fatigue - etiology Glucagon Glucose Glycated Hemoglobin A - analysis Growth hormones Hematology Humans Hyperglycemia Hyperglycemia - etiology Hypertension Hypoglycemia Hypothyroidism Illnesses Immune Checkpoint Inhibitors - adverse effects Insulin resistance Lung Neoplasms - drug therapy Lung Neoplasms - secondary Male Malnutrition Melanoma Melanoma - drug therapy Melanoma - secondary Mens health Metabolic syndrome Metastases Metastasis Oncology Oncology General Thirst Thyroid Disease Thyroid gland Treatments in Oncology Weight Loss
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Beschreibung
Zusammenfassung:	A 68-year-old man with metastatic melanoma was evaluated in the oncology clinic because of fatigue and weight loss. Hypothyroidism had been noted 4 months earlier; increased thirst and nocturia had developed 2 weeks earlier. The blood glucose level was 505 mg per deciliter (reference range, 70 to 110). Management decisions were made.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMcpc2115848