Nfkbid-mediated humoral immunity during secondary toxoplasmosis

Nfkbid-mediated humoral immunity during secondary toxoplasmosis

Vaccine-mediated immunity to parasites has not been achieved. Immune C57BL/6 mice are susceptible to secondary Toxoplasma gondii infection. Using a forward genetics approach, Souza et al. identify Nfkbid as an important factor for the regulation of B cell immunity during secondary Toxoplasma infecti...

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Veröffentlicht in:Trends in parasitology 2022-04, Vol.38 (4), p.272-273
Hauptverfasser: Khan, Imtiaz A., Moretto, Magali
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antibodies, Protozoan
B cells
CD8 T cells
Immunity, Cellular
Immunity, Humoral
Mice
Mice, Inbred C57BL
Nfkbid
Protozoan Proteins
Protozoan Vaccines
Toxoplasma - genetics
Toxoplasma gondii
Toxoplasmosis
Toxoplasmosis, Animal
vaccine
Vaccines, DNA
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Beschreibung
Zusammenfassung:Vaccine-mediated immunity to parasites has not been achieved. Immune C57BL/6 mice are susceptible to secondary Toxoplasma gondii infection. Using a forward genetics approach, Souza et al. identify Nfkbid as an important factor for the regulation of B cell immunity during secondary Toxoplasma infection and protection against rechallenge.
ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2022.01.010