Facile synthesis of the spiro-pyridoindolone scaffold via a gold-catalysed intramolecular alkynol cyclisation/hydroindolylation

Facile synthesis of the spiro-pyridoindolone scaffold via a gold-catalysed intramolecular alkynol cyclisation/hydroindolylation

A simple approach for the synthesis of pyridoindolone scaffolds with a spiroannulated tetrahydrofuran ring is described. The overall process comprises intramolecular sequential gold-catalysed 5- alkynol cycloisomerization and subsequent addition of indole C2 to the generated oxocarbenium cation.

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Veröffentlicht in:Organic & biomolecular chemistry 2022-03, Vol.20 (10), p.2086-2095
Hauptverfasser: Shinde, Mahesh H, Ramana, Chepuri V
Format: Artikel
Sprache:eng
Schlagworte:
Gold
Isomerization
Scaffolds
Tetrahydrofuran
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Zusammenfassung:A simple approach for the synthesis of pyridoindolone scaffolds with a spiroannulated tetrahydrofuran ring is described. The overall process comprises intramolecular sequential gold-catalysed 5- alkynol cycloisomerization and subsequent addition of indole C2 to the generated oxocarbenium cation.
ISSN:1477-0520
1477-0539
DOI:10.1039/d1ob02483c