Aspergichromones A-E, Five Chromone Derivatives with Complicated Polycyclic Architecture from Aspergillus deflectus

Five unprecedented chromone derivatives involving a 6/6/5/5/5/6 hexacyclic scaffold ( , ), 6/6/5/6/6/6/6 heptacyclic scaffold ( ), and 6/6/6/5/5/6 hexacyclic scaffold ( , ) were obtained from the fungus NCC0415. Their structures were identified using comprehensive spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Except for , the other compounds, especially the 6/6/6/5/5/6 hexacyclic derivatives ( and ), exhibited potent inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitory activities.