Current management of children with hepatitis C virus mother‐to‐child transmission

2 Prevalence is lower in children, estimated at 0.012% at ages 5–9 years, 0.010% at 10–14 years, and 0.022% at 15–19 years. 2 In 2018, the hepatology group of the Japanese Society for Pediatric Gastroenterology, Hepatology and Nutrition (JSPGHAN) investigated the epidemiologic features of Japanese children born from 1986 to 2015 with HCV infection to clarify natural history and trends over the last three decades. 3 Features of the patients were evaluated in three groups defined by birth year: 1986–1995, 1996–2005, and 2006–2015. 3 Histopathological examination revealed that the classification of fibrosis according to the new Inuyama classification (defined by F0 to F4); F0 33%, F1 58%, F2 9%, and F3-4 0%, indicating that there was no case in which fibrosis progressed to the level of F3 or higher. 3 None of Japanese HCV children developed. 3 Table 1 Putative types of exposure to HCV infection in 348 children 3 Total (n = 348) Group 1 1986–1995 (n = 49) Group 2 1996–2005 (n = 175) Group 3 2006–2015 (n = 124) P values † Maternal, n (%) * 314 (90) 30 (61) 161 (92) 123 (99)