XaaP-ing DPP8/9 for CARD8 activation

Inflammasomes are cytosolic immune complexes that initiate inflammatory signaling upon pathogen recognition. A new paper reveals that inhibition of M24B aminopeptidases drives the selective activation of the CARD8 inflammasome, providing new insights into its regulation.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature chemical biology 2022-05, Vol.18 (5), p.439-440
Hauptverfasser:	Kulsuptrakul, Jessie, Mitchell, Patrick S.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250 631/92/468 631/92/609 631/92/613 Amino acids Antigen-antibody complexes Apoptosis Regulatory Proteins Biochemical Engineering Biochemistry Biology Bioorganic Chemistry Catalysis Cell Biology Chemistry Chemistry and Materials Science Chemistry/Food Science Inflammasomes Inflammation News & Views news-and-views Pathogens Peptides
Online-Zugang:	Volltext
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