XaaP-ing DPP8/9 for CARD8 activation

XaaP-ing DPP8/9 for CARD8 activation

Inflammasomes are cytosolic immune complexes that initiate inflammatory signaling upon pathogen recognition. A new paper reveals that inhibition of M24B aminopeptidases drives the selective activation of the CARD8 inflammasome, providing new insights into its regulation.

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Bibliographische Detailangaben
Veröffentlicht in:Nature chemical biology 2022-05, Vol.18 (5), p.439-440
Hauptverfasser: Kulsuptrakul, Jessie, Mitchell, Patrick S.
Format: Artikel
Sprache:eng
Schlagworte:
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Amino acids
Antigen-antibody complexes
Apoptosis Regulatory Proteins
Biochemical Engineering
Biochemistry
Biology
Bioorganic Chemistry
Catalysis
Cell Biology
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inflammasomes
Inflammation
News & Views
news-and-views
Pathogens
Peptides
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Beschreibung
Zusammenfassung:Inflammasomes are cytosolic immune complexes that initiate inflammatory signaling upon pathogen recognition. A new paper reveals that inhibition of M24B aminopeptidases drives the selective activation of the CARD8 inflammasome, providing new insights into its regulation.
ISSN:1552-4450
1552-4469
DOI:10.1038/s41589-021-00958-5