Putting the antibiotics chloramphenicol and linezolid into context

Growing evidence suggests that many ribosome-targeting antibiotics inhibit protein synthesis context specifically, which has important implications for drug development. New work reveals the structural basis of context-specific action of the classic translation inhibitor chloramphenicol and the oxaz...

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Veröffentlicht in:	Nature structural & molecular biology 2022-02, Vol.29 (2), p.79-81
Hauptverfasser:	Crowe-McAuliffe, Caillan, Wilson, Daniel N.
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 631/45/500 631/535/1258/1259 631/535/1266 Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibiotics Bacteria - drug effects Bacteria - genetics Bacteria - metabolism Biochemistry Biological Microscopy Biomedical and Life Sciences Chloramphenicol Chloramphenicol - chemistry Chloramphenicol - pharmacology Chloromycetin Context Drug Development Drug Resistance, Bacterial - genetics Humans Life Sciences Linezolid Linezolid - chemistry Linezolid - pharmacology Membrane Biology Models, Molecular News & Views news-and-views Oxazolidinones Oxazolidinones - chemistry Oxazolidinones - pharmacology Protein biosynthesis Protein Biosynthesis - drug effects Protein Structure Protein synthesis Protein Synthesis Inhibitors - chemistry Protein Synthesis Inhibitors - pharmacology Ribosomes - drug effects Ribosomes - metabolism Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	Growing evidence suggests that many ribosome-targeting antibiotics inhibit protein synthesis context specifically, which has important implications for drug development. New work reveals the structural basis of context-specific action of the classic translation inhibitor chloramphenicol and the oxazolidinones linezolid and radezolid.
ISSN:	1545-9993 1545-9985
DOI:	10.1038/s41594-022-00725-7