Pas-de-deux: African Plasmodium falciparum adaptations to sickle hemoglobin
The molecular arms race between humans and Plasmodium falciparum in Africa resulted in selection of sickle-cell disease, which, on balance, protects heterozygote carriers against severe malaria. Band et al. discovered that parasites counter-adapt and can overcome disease resistance by identifying pa...
Gespeichert in:
| Veröffentlicht in: | Trends in parasitology 2022-04, Vol.38 (4), p.267-268 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 268 |
|---|---|
| container_issue | 4 |
| container_start_page | 267 |
| container_title | Trends in parasitology |
| container_volume | 38 |
| creator | Matuschewski, Kai Maier, Alexander G. |
| description | The molecular arms race between humans and Plasmodium falciparum in Africa resulted in selection of sickle-cell disease, which, on balance, protects heterozygote carriers against severe malaria. Band et al. discovered that parasites counter-adapt and can overcome disease resistance by identifying parasite genome signatures, termed P. falciparum sickle-associated (Pfsa) variants. |
| doi_str_mv | 10.1016/j.pt.2022.01.009 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2628696393</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1471492222000101</els_id><sourcerecordid>2628696393</sourcerecordid><originalsourceid>FETCH-LOGICAL-c303t-20c7f72ebc830cb55524d06515b0e4c4cd9d814e3e06e31dca74c3851a0423003</originalsourceid><addsrcrecordid>eNp1kL1PwzAQxS0EoqWwM6GMLAlnOx9NtwrxJSrRAWbLsS_gksTBThD897hqYUN30r3hd093j5BzCgkFml9tkn5IGDCWAE0AygMypWlB4wygONzrtGRsQk683wDQrCjKYzLhGQ1VwJQ8rqWPNYYevxbRsnZGyS5aN9K3VpuxjWrZKNNLF6TUsh_kYGzno8FG3qj3BqM3bO1rYyvTnZKjQHs8288Zebm9eb6-j1dPdw_Xy1WsOPAhZqCKumBYqTkHVWVZxlINeTioAkxVqnSp5zRFjpAjp1rJIlV8nlEJKeMAfEYud769sx8j-kG0xitsGtmhHb1gOZvnZc5LHlDYocpZ7x3Wonemle5bUBDbCMVG9IPYRiiAihBhWLnYu49Vi_pv4TezACx2AIYfPw064ZXBTqE2DtUgtDX_u_8AfVN_5A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2628696393</pqid></control><display><type>article</type><title>Pas-de-deux: African Plasmodium falciparum adaptations to sickle hemoglobin</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Matuschewski, Kai ; Maier, Alexander G.</creator><creatorcontrib>Matuschewski, Kai ; Maier, Alexander G.</creatorcontrib><description>The molecular arms race between humans and Plasmodium falciparum in Africa resulted in selection of sickle-cell disease, which, on balance, protects heterozygote carriers against severe malaria. Band et al. discovered that parasites counter-adapt and can overcome disease resistance by identifying parasite genome signatures, termed P. falciparum sickle-associated (Pfsa) variants.</description><identifier>ISSN: 1471-4922</identifier><identifier>EISSN: 1471-5007</identifier><identifier>DOI: 10.1016/j.pt.2022.01.009</identifier><identifier>PMID: 35151570</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>allele frequency ; Anemia, Sickle Cell - genetics ; Animals ; balanced polymorphism ; genetic epidemiology ; hemoglobin S ; Hemoglobin, Sickle - genetics ; Humans ; Malaria ; Malaria, Falciparum - parasitology ; Parasites ; Plasmodium falciparum - genetics ; severe malaria ; sickle cell</subject><ispartof>Trends in parasitology, 2022-04, Vol.38 (4), p.267-268</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c303t-20c7f72ebc830cb55524d06515b0e4c4cd9d814e3e06e31dca74c3851a0423003</cites><orcidid>0000-0001-7369-1058 ; 0000-0001-6147-8591</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1471492222000101$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35151570$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matuschewski, Kai</creatorcontrib><creatorcontrib>Maier, Alexander G.</creatorcontrib><title>Pas-de-deux: African Plasmodium falciparum adaptations to sickle hemoglobin</title><title>Trends in parasitology</title><addtitle>Trends Parasitol</addtitle><description>The molecular arms race between humans and Plasmodium falciparum in Africa resulted in selection of sickle-cell disease, which, on balance, protects heterozygote carriers against severe malaria. Band et al. discovered that parasites counter-adapt and can overcome disease resistance by identifying parasite genome signatures, termed P. falciparum sickle-associated (Pfsa) variants.</description><subject>allele frequency</subject><subject>Anemia, Sickle Cell - genetics</subject><subject>Animals</subject><subject>balanced polymorphism</subject><subject>genetic epidemiology</subject><subject>hemoglobin S</subject><subject>Hemoglobin, Sickle - genetics</subject><subject>Humans</subject><subject>Malaria</subject><subject>Malaria, Falciparum - parasitology</subject><subject>Parasites</subject><subject>Plasmodium falciparum - genetics</subject><subject>severe malaria</subject><subject>sickle cell</subject><issn>1471-4922</issn><issn>1471-5007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kL1PwzAQxS0EoqWwM6GMLAlnOx9NtwrxJSrRAWbLsS_gksTBThD897hqYUN30r3hd093j5BzCgkFml9tkn5IGDCWAE0AygMypWlB4wygONzrtGRsQk683wDQrCjKYzLhGQ1VwJQ8rqWPNYYevxbRsnZGyS5aN9K3VpuxjWrZKNNLF6TUsh_kYGzno8FG3qj3BqM3bO1rYyvTnZKjQHs8288Zebm9eb6-j1dPdw_Xy1WsOPAhZqCKumBYqTkHVWVZxlINeTioAkxVqnSp5zRFjpAjp1rJIlV8nlEJKeMAfEYud769sx8j-kG0xitsGtmhHb1gOZvnZc5LHlDYocpZ7x3Wonemle5bUBDbCMVG9IPYRiiAihBhWLnYu49Vi_pv4TezACx2AIYfPw064ZXBTqE2DtUgtDX_u_8AfVN_5A</recordid><startdate>202204</startdate><enddate>202204</enddate><creator>Matuschewski, Kai</creator><creator>Maier, Alexander G.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7369-1058</orcidid><orcidid>https://orcid.org/0000-0001-6147-8591</orcidid></search><sort><creationdate>202204</creationdate><title>Pas-de-deux: African Plasmodium falciparum adaptations to sickle hemoglobin</title><author>Matuschewski, Kai ; Maier, Alexander G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-20c7f72ebc830cb55524d06515b0e4c4cd9d814e3e06e31dca74c3851a0423003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>allele frequency</topic><topic>Anemia, Sickle Cell - genetics</topic><topic>Animals</topic><topic>balanced polymorphism</topic><topic>genetic epidemiology</topic><topic>hemoglobin S</topic><topic>Hemoglobin, Sickle - genetics</topic><topic>Humans</topic><topic>Malaria</topic><topic>Malaria, Falciparum - parasitology</topic><topic>Parasites</topic><topic>Plasmodium falciparum - genetics</topic><topic>severe malaria</topic><topic>sickle cell</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matuschewski, Kai</creatorcontrib><creatorcontrib>Maier, Alexander G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matuschewski, Kai</au><au>Maier, Alexander G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pas-de-deux: African Plasmodium falciparum adaptations to sickle hemoglobin</atitle><jtitle>Trends in parasitology</jtitle><addtitle>Trends Parasitol</addtitle><date>2022-04</date><risdate>2022</risdate><volume>38</volume><issue>4</issue><spage>267</spage><epage>268</epage><pages>267-268</pages><issn>1471-4922</issn><eissn>1471-5007</eissn><abstract>The molecular arms race between humans and Plasmodium falciparum in Africa resulted in selection of sickle-cell disease, which, on balance, protects heterozygote carriers against severe malaria. Band et al. discovered that parasites counter-adapt and can overcome disease resistance by identifying parasite genome signatures, termed P. falciparum sickle-associated (Pfsa) variants.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>35151570</pmid><doi>10.1016/j.pt.2022.01.009</doi><tpages>2</tpages><orcidid>https://orcid.org/0000-0001-7369-1058</orcidid><orcidid>https://orcid.org/0000-0001-6147-8591</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1471-4922 |
| ispartof | Trends in parasitology, 2022-04, Vol.38 (4), p.267-268 |
| issn | 1471-4922 1471-5007 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2628696393 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | allele frequency Anemia, Sickle Cell - genetics Animals balanced polymorphism genetic epidemiology hemoglobin S Hemoglobin, Sickle - genetics Humans Malaria Malaria, Falciparum - parasitology Parasites Plasmodium falciparum - genetics severe malaria sickle cell |
| title | Pas-de-deux: African Plasmodium falciparum adaptations to sickle hemoglobin |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T13%3A47%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pas-de-deux:%20African%20Plasmodium%20falciparum%20adaptations%20to%20sickle%20hemoglobin&rft.jtitle=Trends%20in%20parasitology&rft.au=Matuschewski,%20Kai&rft.date=2022-04&rft.volume=38&rft.issue=4&rft.spage=267&rft.epage=268&rft.pages=267-268&rft.issn=1471-4922&rft.eissn=1471-5007&rft_id=info:doi/10.1016/j.pt.2022.01.009&rft_dat=%3Cproquest_cross%3E2628696393%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2628696393&rft_id=info:pmid/35151570&rft_els_id=S1471492222000101&rfr_iscdi=true |