Pas-de-deux: African Plasmodium falciparum adaptations to sickle hemoglobin

The molecular arms race between humans and Plasmodium falciparum in Africa resulted in selection of sickle-cell disease, which, on balance, protects heterozygote carriers against severe malaria. Band et al. discovered that parasites counter-adapt and can overcome disease resistance by identifying pa...

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Veröffentlicht in:	Trends in parasitology 2022-04, Vol.38 (4), p.267-268
Hauptverfasser:	Matuschewski, Kai, Maier, Alexander G.
Format:	Artikel
Sprache:	eng
Schlagworte:	allele frequency Anemia, Sickle Cell - genetics Animals balanced polymorphism genetic epidemiology hemoglobin S Hemoglobin, Sickle - genetics Humans Malaria Malaria, Falciparum - parasitology Parasites Plasmodium falciparum - genetics severe malaria sickle cell
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Beschreibung
Zusammenfassung:	The molecular arms race between humans and Plasmodium falciparum in Africa resulted in selection of sickle-cell disease, which, on balance, protects heterozygote carriers against severe malaria. Band et al. discovered that parasites counter-adapt and can overcome disease resistance by identifying parasite genome signatures, termed P. falciparum sickle-associated (Pfsa) variants.
ISSN:	1471-4922 1471-5007
DOI:	10.1016/j.pt.2022.01.009