3D Printed Platelet-Rich Plasma-Loaded Scaffold with Sustained Cytokine Release for Bone Defect Repair
The combination of three-dimensional (3D) printed scaffold materials and various cytokines can achieve the purpose of tissue reconstruction more efficiently. In this study, we prepared platelet-rich plasma (PRP)/gelatin microspheres combined with 3D printed polycaprolactone/β-tricalcium phosphate sc...
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| Veröffentlicht in: | Tissue engineering. Part A 2022-08, Vol.28 (15-16), p.7-711 |
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| container_issue | 15-16 |
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| container_title | Tissue engineering. Part A |
| container_volume | 28 |
| creator | Liu, Chun Peng, Ziyue Xu, Haixia Gao, Huiling Li, Jianjun Jin, Yanglei Wang, Yihan Wang, Chengqiang Liu, Yang Hu, Yunteng Jiang, Cong Guo, Jiasong Zhu, Lixin |
| description | The combination of three-dimensional (3D) printed scaffold materials and various cytokines can achieve the purpose of tissue reconstruction more efficiently. In this study, we prepared platelet-rich plasma (PRP)/gelatin microspheres combined with 3D printed polycaprolactone/β-tricalcium phosphate scaffolds to solve the key problem that PRP cannot be released under control and the release time is too short, and thus better promote bone repair. Consequently, the composite scaffold displayed a good mechanical property and sustained cytokine release for ∼3 weeks. Increased survival, proliferation, migration, and osteogenic and angiogenic differentiation of bone marrow mesenchymal stem cells were observed compared with the control groups. The
in vivo
study demonstrated that the composite scaffold with PRP/gelatin microspheres led to greater positive effects in promoting large bone defect repair. In conclusion, in this study, a new type of PRP long-term sustained-release composite scaffold material was constructed that effectively improved the survival, proliferation, and differentiation of cells in the transplanted area, thereby better promoting the repair of large bone defects. |
| doi_str_mv | 10.1089/ten.tea.2021.0211 |
| format | Article |
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in vivo
study demonstrated that the composite scaffold with PRP/gelatin microspheres led to greater positive effects in promoting large bone defect repair. In conclusion, in this study, a new type of PRP long-term sustained-release composite scaffold material was constructed that effectively improved the survival, proliferation, and differentiation of cells in the transplanted area, thereby better promoting the repair of large bone defects.</description><identifier>ISSN: 1937-3341</identifier><identifier>EISSN: 1937-335X</identifier><identifier>DOI: 10.1089/ten.tea.2021.0211</identifier><language>eng</language><publisher>New Rochelle: Mary Ann Liebert, Inc., publishers</publisher><subject>Angiogenesis ; Blood vessels ; Bone healing ; Bone marrow ; Calcium phosphates ; Cell differentiation ; Cell proliferation ; Controlled release ; Cytokines ; Gelatin ; Mesenchyme ; Microspheres ; Original Articles ; Osteogenesis ; Platelets ; Polycaprolactone ; Stem cells ; Tricalcium phosphate</subject><ispartof>Tissue engineering. Part A, 2022-08, Vol.28 (15-16), p.7-711</ispartof><rights>2022, Mary Ann Liebert, Inc., publishers</rights><rights>Copyright Mary Ann Liebert, Inc. Aug 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c284t-c7099829512fdaacadd8760aa691ee216eacae5cce8fb20df0d2b635bbfb54d03</citedby><cites>FETCH-LOGICAL-c284t-c7099829512fdaacadd8760aa691ee216eacae5cce8fb20df0d2b635bbfb54d03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Liu, Chun</creatorcontrib><creatorcontrib>Peng, Ziyue</creatorcontrib><creatorcontrib>Xu, Haixia</creatorcontrib><creatorcontrib>Gao, Huiling</creatorcontrib><creatorcontrib>Li, Jianjun</creatorcontrib><creatorcontrib>Jin, Yanglei</creatorcontrib><creatorcontrib>Wang, Yihan</creatorcontrib><creatorcontrib>Wang, Chengqiang</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Hu, Yunteng</creatorcontrib><creatorcontrib>Jiang, Cong</creatorcontrib><creatorcontrib>Guo, Jiasong</creatorcontrib><creatorcontrib>Zhu, Lixin</creatorcontrib><title>3D Printed Platelet-Rich Plasma-Loaded Scaffold with Sustained Cytokine Release for Bone Defect Repair</title><title>Tissue engineering. Part A</title><description>The combination of three-dimensional (3D) printed scaffold materials and various cytokines can achieve the purpose of tissue reconstruction more efficiently. In this study, we prepared platelet-rich plasma (PRP)/gelatin microspheres combined with 3D printed polycaprolactone/β-tricalcium phosphate scaffolds to solve the key problem that PRP cannot be released under control and the release time is too short, and thus better promote bone repair. Consequently, the composite scaffold displayed a good mechanical property and sustained cytokine release for ∼3 weeks. Increased survival, proliferation, migration, and osteogenic and angiogenic differentiation of bone marrow mesenchymal stem cells were observed compared with the control groups. The
in vivo
study demonstrated that the composite scaffold with PRP/gelatin microspheres led to greater positive effects in promoting large bone defect repair. In conclusion, in this study, a new type of PRP long-term sustained-release composite scaffold material was constructed that effectively improved the survival, proliferation, and differentiation of cells in the transplanted area, thereby better promoting the repair of large bone defects.</description><subject>Angiogenesis</subject><subject>Blood vessels</subject><subject>Bone healing</subject><subject>Bone marrow</subject><subject>Calcium phosphates</subject><subject>Cell differentiation</subject><subject>Cell proliferation</subject><subject>Controlled release</subject><subject>Cytokines</subject><subject>Gelatin</subject><subject>Mesenchyme</subject><subject>Microspheres</subject><subject>Original Articles</subject><subject>Osteogenesis</subject><subject>Platelets</subject><subject>Polycaprolactone</subject><subject>Stem cells</subject><subject>Tricalcium phosphate</subject><issn>1937-3341</issn><issn>1937-335X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqNkD9PwzAQxSMEEqXwAdgisbAk2E7jJCO0_JMqUbUgsVkX-6ympHGxHaF-exwVMTAxnO787vdO1ouiS0pSSsrqxmOXeoSUEUbTUPQoGtEqK5Isy9-Pf-cJPY3OnNsQwgkvilGks1m8sE3nUcWLFjy26JNlI9fDy20hmRtQYbeSoLVpVfzV-HW86p2Hpgv6dO_NR5jiZXCCw1gbG9-ZIMxQo_RB30Fjz6MTDa3Di58-jt4e7l-nT8n85fF5ejtPJCsnPpEFqaqSVTllWgFIUKosOAHgFUVklGPQMJcSS10zojRRrOZZXte6zieKZOPo-nB3Z81nj86LbeMkti10aHonGGclLzOS04Be_UE3prdd-J1gBSEZLznngaIHSlrjnEUtdrbZgt0LSsSQvAjJhwIxJC-G5IOnOHgGDrqubbBG6__h_AYbbIuG</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Liu, Chun</creator><creator>Peng, Ziyue</creator><creator>Xu, Haixia</creator><creator>Gao, Huiling</creator><creator>Li, Jianjun</creator><creator>Jin, Yanglei</creator><creator>Wang, Yihan</creator><creator>Wang, Chengqiang</creator><creator>Liu, Yang</creator><creator>Hu, Yunteng</creator><creator>Jiang, Cong</creator><creator>Guo, Jiasong</creator><creator>Zhu, Lixin</creator><general>Mary Ann Liebert, Inc., publishers</general><general>Mary Ann Liebert, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20220801</creationdate><title>3D Printed Platelet-Rich Plasma-Loaded Scaffold with Sustained Cytokine Release for Bone Defect Repair</title><author>Liu, Chun ; Peng, Ziyue ; Xu, Haixia ; Gao, Huiling ; Li, Jianjun ; Jin, Yanglei ; Wang, Yihan ; Wang, Chengqiang ; Liu, Yang ; Hu, Yunteng ; Jiang, Cong ; Guo, Jiasong ; Zhu, Lixin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-c7099829512fdaacadd8760aa691ee216eacae5cce8fb20df0d2b635bbfb54d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Angiogenesis</topic><topic>Blood vessels</topic><topic>Bone healing</topic><topic>Bone marrow</topic><topic>Calcium phosphates</topic><topic>Cell differentiation</topic><topic>Cell proliferation</topic><topic>Controlled release</topic><topic>Cytokines</topic><topic>Gelatin</topic><topic>Mesenchyme</topic><topic>Microspheres</topic><topic>Original Articles</topic><topic>Osteogenesis</topic><topic>Platelets</topic><topic>Polycaprolactone</topic><topic>Stem cells</topic><topic>Tricalcium phosphate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Chun</creatorcontrib><creatorcontrib>Peng, Ziyue</creatorcontrib><creatorcontrib>Xu, Haixia</creatorcontrib><creatorcontrib>Gao, Huiling</creatorcontrib><creatorcontrib>Li, Jianjun</creatorcontrib><creatorcontrib>Jin, Yanglei</creatorcontrib><creatorcontrib>Wang, Yihan</creatorcontrib><creatorcontrib>Wang, Chengqiang</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Hu, Yunteng</creatorcontrib><creatorcontrib>Jiang, Cong</creatorcontrib><creatorcontrib>Guo, Jiasong</creatorcontrib><creatorcontrib>Zhu, Lixin</creatorcontrib><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Tissue engineering. Part A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Chun</au><au>Peng, Ziyue</au><au>Xu, Haixia</au><au>Gao, Huiling</au><au>Li, Jianjun</au><au>Jin, Yanglei</au><au>Wang, Yihan</au><au>Wang, Chengqiang</au><au>Liu, Yang</au><au>Hu, Yunteng</au><au>Jiang, Cong</au><au>Guo, Jiasong</au><au>Zhu, Lixin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>3D Printed Platelet-Rich Plasma-Loaded Scaffold with Sustained Cytokine Release for Bone Defect Repair</atitle><jtitle>Tissue engineering. Part A</jtitle><date>2022-08-01</date><risdate>2022</risdate><volume>28</volume><issue>15-16</issue><spage>7</spage><epage>711</epage><pages>7-711</pages><issn>1937-3341</issn><eissn>1937-335X</eissn><abstract>The combination of three-dimensional (3D) printed scaffold materials and various cytokines can achieve the purpose of tissue reconstruction more efficiently. In this study, we prepared platelet-rich plasma (PRP)/gelatin microspheres combined with 3D printed polycaprolactone/β-tricalcium phosphate scaffolds to solve the key problem that PRP cannot be released under control and the release time is too short, and thus better promote bone repair. Consequently, the composite scaffold displayed a good mechanical property and sustained cytokine release for ∼3 weeks. Increased survival, proliferation, migration, and osteogenic and angiogenic differentiation of bone marrow mesenchymal stem cells were observed compared with the control groups. The
in vivo
study demonstrated that the composite scaffold with PRP/gelatin microspheres led to greater positive effects in promoting large bone defect repair. In conclusion, in this study, a new type of PRP long-term sustained-release composite scaffold material was constructed that effectively improved the survival, proliferation, and differentiation of cells in the transplanted area, thereby better promoting the repair of large bone defects.</abstract><cop>New Rochelle</cop><pub>Mary Ann Liebert, Inc., publishers</pub><doi>10.1089/ten.tea.2021.0211</doi><tpages>705</tpages></addata></record> |
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| subjects | Angiogenesis Blood vessels Bone healing Bone marrow Calcium phosphates Cell differentiation Cell proliferation Controlled release Cytokines Gelatin Mesenchyme Microspheres Original Articles Osteogenesis Platelets Polycaprolactone Stem cells Tricalcium phosphate |
| title | 3D Printed Platelet-Rich Plasma-Loaded Scaffold with Sustained Cytokine Release for Bone Defect Repair |
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