The Effect of Fracture Recency on Observed 10‐Year Fracture Probability: A Registry‐Based Cohort Study

The Effect of Fracture Recency on Observed 10‐Year Fracture Probability: A Registry‐Based Cohort Study

ABSTRACT FRAX estimates 10‐year fracture major osteoporotic fracture (MOF) and hip fracture probability from multiple risk factors. FRAX does not consider prior fracture site or time since fracture. Fracture risk is greater in the initial 2‐year post‐fracture period (imminent risk), implying that FR...

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Veröffentlicht in:Journal of bone and mineral research 2022-05, Vol.37 (5), p.848-855
Hauptverfasser: Leslie, William D, Morin, Suzanne N, Lix, Lisa M, McCloskey, Eugene V, Johansson, Helena, Harvey, Nicholas C, Kanis, John A
Format: Artikel
Sprache:eng
Schlagworte:
Bone Density
Bone mineral density
Cohort analysis
Cohort Studies
Female
Forearm
FRACTURE
Fractures
FRAX
Hip
Hip Fractures - complications
Humans
Humerus
IMMINENT RISK
MAJOR OSTEOPOROTIC FRACTURE
OSTEOPOROSIS
Osteoporotic Fractures - epidemiology
Osteoporotic Fractures - etiology
Population-based studies
POPULATION‐BASED COHORT STUDY
Registries
Risk Assessment
Risk Factors
Vertebrae
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Zusammenfassung:ABSTRACT FRAX estimates 10‐year fracture major osteoporotic fracture (MOF) and hip fracture probability from multiple risk factors. FRAX does not consider prior fracture site or time since fracture. Fracture risk is greater in the initial 2‐year post‐fracture period (imminent risk), implying that FRAX may underestimate risk in this setting. We used the population‐based Manitoba Bone Mineral Density (BMD) Program registry to examine the effect of fracture recency and site on incident fracture risk predictions using FRAX. We identified women aged 40 years or older with baseline BMD and FRAX scores. Observed fracture outcomes to 10 years were compared with predicted 10‐year fracture probability stratified by prior fracture status: none, recent (
ISSN:0884-0431
1523-4681
DOI:10.1002/jbmr.4526