Immune sensing of microbial metabolites: Action at the tumor
The microbiome affects establishment and growth of tumors as well as response to immune-based therapies. In this issue of Immunity, Hezaveh et al. (2022) reveal that metabolites of dietary tryptophan generated by the gut microbiota activate the aryl hydrocarbon receptor in myeloid cells, promoting a...
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| Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 2022-02, Vol.55 (2), p.192-194 |
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| container_title | Immunity (Cambridge, Mass.) |
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| creator | Frankel, Timothy L Pasca di Magliano, Marina |
| description | The microbiome affects establishment and growth of tumors as well as response to immune-based therapies. In this issue of Immunity, Hezaveh et al. (2022) reveal that metabolites of dietary tryptophan generated by the gut microbiota activate the aryl hydrocarbon receptor in myeloid cells, promoting an immune suppressive tumor microenvironment and facilitating pancreatic ductal adenocarcinoma growth. |
| doi_str_mv | 10.1016/j.immuni.2022.01.009 |
| format | Article |
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| ispartof | Immunity (Cambridge, Mass.), 2022-02, Vol.55 (2), p.192-194 |
| issn | 1074-7613 1097-4180 |
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| source | MEDLINE; Cell Press Free Archives; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals |
| subjects | Gastrointestinal Microbiome - immunology Humans Microbiota Neoplasms Receptors, Aryl Hydrocarbon - metabolism Tryptophan - metabolism Tumor Microenvironment |
| title | Immune sensing of microbial metabolites: Action at the tumor |
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