Immune sensing of microbial metabolites: Action at the tumor

Immune sensing of microbial metabolites: Action at the tumor

The microbiome affects establishment and growth of tumors as well as response to immune-based therapies. In this issue of Immunity, Hezaveh et al. (2022) reveal that metabolites of dietary tryptophan generated by the gut microbiota activate the aryl hydrocarbon receptor in myeloid cells, promoting a...

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Veröffentlicht in:Immunity (Cambridge, Mass.) Mass.), 2022-02, Vol.55 (2), p.192-194
Hauptverfasser: Frankel, Timothy L, Pasca di Magliano, Marina
Format: Artikel
Sprache:eng
Schlagworte:
Gastrointestinal Microbiome - immunology
Humans
Microbiota
Neoplasms
Receptors, Aryl Hydrocarbon - metabolism
Tryptophan - metabolism
Tumor Microenvironment
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Zusammenfassung:The microbiome affects establishment and growth of tumors as well as response to immune-based therapies. In this issue of Immunity, Hezaveh et al. (2022) reveal that metabolites of dietary tryptophan generated by the gut microbiota activate the aryl hydrocarbon receptor in myeloid cells, promoting an immune suppressive tumor microenvironment and facilitating pancreatic ductal adenocarcinoma growth.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2022.01.009