Hypervitaminosis A with fulminant secondary intracranial hypertension following personalized medicine-based Elexacaftor/Tezacaftor/Ivacaftor initiation in a preadolescent with cystic fibrosis

•CFTR modulators can increase Vitamin A absorption resulting in Hypervitaminosis A.•Elevated Serum Retinol can cause secondary intracranial hypertension.•Emergent management of fulminant intracranial hypertension is crucial.•Serial monitoring for vitamin toxicity in CF remains important.•Reporting complications of CFTR modulators is necessary for anticipatory guidance.