Differential effects of statins on matrix metalloproteinase-9 (MMP-9) in patients with acute ischaemic stroke: A potential for salutary

To illustrate the differential outcome of atorvastatin versus rosuvastatin on matrix metalloproteinases (MMP-9) in patients with acute ischaemic stroke (AIS). The case-control study was done in the Department of Clinical Pharmacology and Therapeutic, Mustansiriyah University, Baghdad, Iraq, from March to June, 2020 and involved 66 AIS patients and 22 healthy controls. They sub-grouped into Group A: AIS patient on statins therapy (n=44), with 22 on atorvastatin and 22 on rosuvastatin. Group B: AIS patients not on statins therapy (n=22). Anthropometric, lipid, and pressure profiles were evaluated. As well, MMP-9 level was estimated in different treated groups. SPSS version 20.00 was used for data analysis. MMP-9 level was greater in patients with AIS (19.69±7.49 ng/dL) mainly those not on statin therapy (28.24±12.14 ng/dL) compared to the controls (10.54±1.92 ng/dL), (P=0.003). Regarding the differential effect of statins therapy on MMP-9 serum level in patients with AIS, it was (20.63±5.67 ng/dL) in patients on atorvastatin therapy and (19.69±5.41 ng/dL) in patients on rosuvastatin therapy, (P=0.57). MMP-9 serum level was highly correlated with stroke risk score (SRS) in patients with AIS not on statins therapy (P