Synthesis of some novel 2(1H)-quinazolinones and 2-thioxo analogues from newly synthesised 1-acyl-3-alkoxyphenylureas and thioureas

A convenient route for the synthesis of new 2(1H)‐quinazolinones (IIc—h) and 2(1H)‐quinazolinethiones (IIi—j) is discussed. It involves the cyclodehydration of 1‐acyl‐3‐(alkoxyphenyl)ureas (Ic—h) and the corresponding thioureas (Ii—j) in polyphosphoric acid. Elucidation of structures of the isolated...

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Veröffentlicht in:	Journal of chemical technology and biotechnology (1986) 1993, Vol.58 (4), p.391-394
Hauptverfasser:	Jaeda, Mousa I., Abdel-Samii, Zakaria K., Britten, A. Z.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-acyl-3-(alkoxyphenyl)thioureas 1-acyl-3-(alkoxyphenyl)ureas 2(1H)-quinazolinethiones 2(1H)-quinazolinones Chemistry cyclodehydration reaction Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Organic chemistry polyphosphoric acid Preparations and properties
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Beschreibung
Zusammenfassung:	A convenient route for the synthesis of new 2(1H)‐quinazolinones (IIc—h) and 2(1H)‐quinazolinethiones (IIi—j) is discussed. It involves the cyclodehydration of 1‐acyl‐3‐(alkoxyphenyl)ureas (Ic—h) and the corresponding thioureas (Ii—j) in polyphosphoric acid. Elucidation of structures of the isolated products have been proved in the light of their elemental analysis and spectroscopic data.
ISSN:	0268-2575 1097-4660
DOI:	10.1002/jctb.280580413