Prospective, Multi‐Center Study of the Anatomic Distribution of Recurrent Respiratory Papillomatosis

Objectives/Hypothesis To create a model of the anatomic distribution, recurrence, and growth patterns of recurrent respiratory papillomatosis (RRP). Study Design Prospective, multi‐institutional cohort study. Methods Adult patients with a diagnosis of RRP evaluated between August 1, 2018 and February 1, 2021 at six participating centers were invited to enroll. At each office or operating room encounter, laryngologists recorded the location and size of RRP lesions using a 22‐region schematic. A generalized linear mixed effects model was used to compare region variations in lesion prevalence and recurrence. Results The cohort comprised 121 patients: 74% were male, 81% had been diagnosed with adult‐onset RRP, and a plurality (34%) had undergone 0 to 3 RRP interventions prior to enrollment. Across the study period, the odds of a lesion occurring in the glottis was significantly higher (odds ratio [OR]: 26.51; 95% confidence interval [CI]: 11.76–59.75, P