Serum testosterone concentrations are not associated with frailty in naturally ageing and testosterone-deficient older C57Bl/6 mice

Serum testosterone concentrations are not associated with frailty in naturally ageing and testosterone-deficient older C57Bl/6 mice

This study investigated how serum testosterone related to frailty in ageing male C57Bl/6 mice with or without lifelong testosterone deficiency. Mice underwent a sham surgery (n = 10) or gonadectomy (n = 11, GDX) at 4-weeks and then aged. Frailty scores (31-item frailty index) and testosterone were m...

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Veröffentlicht in:Mechanisms of ageing and development 2022-04, Vol.203, p.111638-111638, Article 111638
Hauptverfasser: Heinze-Milne, Stefan D., Banga, Shubham, Godin, Judith, Howlett, Susan E.
Format: Artikel
Sprache:eng
Schlagworte:
AFRAID clock
Ageing
Aging
Animal model
Animals
Frailty
FRIGHT clock
Hormones
Life Expectancy
Male
Mice
Mice, Inbred C57BL
Testosterone
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Zusammenfassung:This study investigated how serum testosterone related to frailty in ageing male C57Bl/6 mice with or without lifelong testosterone deficiency. Mice underwent a sham surgery (n = 10) or gonadectomy (n = 11, GDX) at 4-weeks and then aged. Frailty scores (31-item frailty index) and testosterone were measured between 18- to 24-months of age. Age predicted frailty (p 
ISSN:0047-6374
1872-6216
DOI:10.1016/j.mad.2022.111638