An anion channel for cyclic dinucleotides in T cells

LRRC8C is an essential component of volume-regulated anion channel (VRAC) in T cells. By mediating the transport of cGAMP, LRRC8C inhibits T cell function by activating STING and the tumor suppressor p53.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature immunology 2022-02, Vol.23 (2), p.157-158
Hauptverfasser:	Chu, Jiachen, Qiu, Zhaozhu
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554 631/250/516 Adaptive immunity Anions Apoptosis Bacteria Biomedical and Life Sciences Biomedicine Cell cycle Cell growth Dinucleoside Phosphates Families & family life Gene expression Genotype & phenotype Immunology Infections Infectious Diseases Influenza Kinases Lymphocytes Lymphocytes T Multiple sclerosis News & Views news-and-views T-Lymphocytes Tumor suppressor genes Tumors Viral infections Viruses
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Beschreibung
Zusammenfassung:	LRRC8C is an essential component of volume-regulated anion channel (VRAC) in T cells. By mediating the transport of cGAMP, LRRC8C inhibits T cell function by activating STING and the tumor suppressor p53.
ISSN:	1529-2908 1529-2916
DOI:	10.1038/s41590-021-01118-6