Placental pathology of term singleton live births conceived with fresh embryo transfer compared with those conceived without assisted reproductive technology

To compare placental pathology from term singleton live births conceived with fresh embryo transfer vs. those conceived without assisted reproductive technology (ART). Retrospective cohort study. Academic fertility center. Women with a term singleton live birth who conceived after fresh autologous in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles (ART group) and those who conceived without ART. An experienced placental pathologist categorized placental pathology as anatomic, inflammatory, or vascular. Patient characteristics were compared by chi-squared tests, Student’s t-test, or nonparametric tests. Multivariate logistic regression models were used to compare placental pathology between pregnancies conceived with and without ART. Incidence of anatomic, inflammatory, and vascular placental pathology. There was a higher incidence of placental pathology in the ART group (n = 511) than in the non-ART group (n = 121), specifically anatomic (adjusted odds ratio [aOR] 2.50, 95% confidence interval [CI] 1.42–4.40) and vascular (aOR 2.00, 95% CI 1.13–3.53) pathology. These findings were driven primarily by the significantly higher odds of anatomic (aOR 2.97, 95% CI 1.55–5.66) and vascular (aOR 1.98, 95% CI 1.04–3.75) pathology observed in ICSI pregnancies. Single blastocyst transfers remained associated with increased anatomic pathology (ART: aOR 4.89, 95% CI 2.28–10.49; ICSI: aOR 3.38, 95% CI 1.49–7.71). Fresh embryo transfer is associated with increased anatomic and vascular placental pathology in term singleton live births compared with conception without ART. This finding should be investigated prospectively in a larger cohort of patients. Patología placentaria de fetos únicos nacidos a término concebidos tras transferencia de embriones frescos en comparación con los concebido sin técnicas de Reproducción asistida. Comparar la patología placentaria de fetos únicos nacidos a término concebidos tras transferencia de embriones frescos con aquellos concebidos sin técnicas de Reproducción asistida (TRA). Estudio de cohorte retrospectivo. Centro académico de fertilidad. Mujeres con un nacido vivo único a término que han concebido después de una fertilización in vitro (FIV) autóloga en fresco/ ciclos de inyección intracitoplasmática de esperma (ICSI) (grupo ART) y aquellas que han concebido sin TRA. Un patólogo placentario experimentado clasificó la patología placentaria como anatómica, inflamatoria o vascular. Las características de la pac